Abstract
This work describes the optimization and adoption of an assay system for the Human Immunodeficiency Virus (HIV)-protease, whose inhibition plays a central role in HIV therapy. The HIV-protease, which is an essential enzyme during viral maturation, has a specific cleavage site of eight amino acid residues (SQNY*PIV). Adding two amino acid residues at the N-terminus and enclosing the resulting sequence by a dye-labelled lysine residue and a tryptophan residue leads to the substrate (K(dye)CGSQNY*P
Sprache: English
Art der Begutachtung: Peer Review(Double-blind peer review)
Print: Ja
Online: Ja, ohne Open Access
Datenmedium: Keine Angabe
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